NDC 21922008652Generic / Multi-Source

ESTRADIOL 0.1% (0.25 MG) GEL PK

Also sold as: ESTRACE, CLIMARA, VIVELLE

$1.7061

NADAC per EA

$51.18

Est. 30-day supply*

$153.55

Est. 90-day supply*

Jan 7, 2026

Price survey date

* Supply estimates are based on NADAC acquisition cost only (30 or 90 tablets/capsules). Your actual pharmacy cost will be higher due to dispensing fees and markup.

1What is this price?

The price shown is NADAC (National Average Drug Acquisition Cost) — what pharmacies across the US actually pay their suppliers for this drug, surveyed weekly by CMS/Medicaid. Think of it as the wholesale floor price. Your out-of-pocket cost at the pharmacy will be higher, since pharmacies add a dispensing fee (typically $3–$12) and a markup to cover their overhead.

2Why can't we show what your insurance pays?

Unlike hospital prices — which are now legally required to be published — drug prices negotiated between insurers and pharmacies are trade secrets. Pharmacy Benefit Managers (PBMs) like CVS Caremark, Express Scripts, and OptumRx negotiate confidential rates on behalf of insurers. What your plan pays, and what your copay will be, depends on:

Which PBM manages your plan's drug benefit
What tier this drug is on your plan's formulary (Tier 1–5)
Whether you've met your deductible yet
Whether your plan uses copays (flat fee) or coinsurance (percentage)
Whether the drug requires prior authorization

To find your specific cost: check your plan's drug formulary online, call the number on your insurance card, or ask your pharmacist to run it through your insurance before you pick up.

3How to use this information

Compare to your copay

If your insurance copay is close to or below the NADAC price, you may actually save money paying cash — especially for cheap generics.

Ask about generics

Brand drugs can cost 80–99% more than their generic equivalent for the same active ingredient. Ask your doctor if a generic is appropriate.

Try discount programs

GoodRx, RxSaver, and similar services negotiate cash prices that are often below insurance copays. Always worth checking before you pay.

Consider cost-plus pharmacies

Mark Cuban's Cost Plus Drugs (costplusdrugs.com) charges NADAC + 15% markup + dispensing fee — one of the most transparent pricing models available.

Not medical or financial advice

Never change your medication based solely on price data. Always consult your doctor or pharmacist before switching drugs, requesting generics, or changing your dosage. NADAC prices are national averages and may not reflect what your specific pharmacy pays or charges.

Other Strengths & Formulations

ESTRADIOL 0.1% (1.25 MG) GEL PK

NDC 45802057330

$1.3982

per GM

ESTRADIOL 0.1% (0.25 MG) GEL PK

NDC 72603024130

$1.7061

per EA

ESTRADIOL 0.1% (1 MG) GEL PKT

NDC 69238244903

$1.7340

per GM

ESTRADIOL 0.1% (0.5 MG) GEL PKT

NDC 21922008752

$1.8372

per EA

Data source: CMS NADAC — updated weekly. This record reflects prices as of January 7, 2026. View source data